Autopsy examines how forensic examiners can help solve crimes. "Pure Evil" looks at the case of Canadian serial rapists and murderers Paul Bernardo and Karla Homolka. "The Lady Vanishes" examines a case where DNA on the envelop of a suicide note helps to establish that a missing woman was being impersonated by her husband. "Mail Rape" a rapist attempts to throw doubt on his case by sending an accomplice a DNA sample in the mail. "Blood Hound of Detroit" a dog trained to sense blood helps lead police to a murderer. "The Medicine Man" a medical examiner thinks that embalming will conceal evidence that he murdered his wife. "Belle of Them All" examines the notorious Norwegian-American serial killer Belle Gunness.
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